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Imveliso

Isithako esisebenzayo: I-Mazdutide

ICandelo leMveliso

I-1.USDAL - i-agonists:

Ii-agonists ezimbini ze-glp -} I-1 Repptor (Glucagon-1) kunye ne-GCGR-Repctor (Glucagon Receptor).

I-AITICICICICICICICT:

I-Glucose yeGlucose yegazi kwi-Difobetes ye-Dielitus (T2DM)

Ukutyeba kakhulu / uLawulo oluninzi (oluvunyiweyo kwamanye amazwe okanye imimandla)

I-Mazddutide iphumeleza iziphumo zonyango kwezi zenzo zimbini zilandelayo:

I-1.Gl-1 I-Readptor Ingxokolo: ikhuthaza ukufihlwa kwe-insulin, ithintele ukukhutshwa kwe-glucagon, kwaye ithole iswekile yegazi. Ukulibaziseka kwe-gustric ekhupha kwaye kwandise imvakalelo yokugcwala.

I-2.GCGR Rector Ingcwebe: iphucula inkcitho yezandla, ikhuthaza imetabolism yamafutha, kwaye iphucula i-hepatic gluconegenesis.

Iithagethi ze-1.IALL: Thelekisa amachiza angatshatanga kwi-GLP-1

2. Ixesha elide {{1} -}} Ithuba lokusebenza ngenkqubela phambili: inaliti engacocekanga kube kanye ngeveki ukomeleza ukuthotyelwa kwesigulana.

3. Izibonelelo ezibanzi zeMetabolic: Ukongeza ekwehliseni iswekile yegazi, inokunciphisa ii-lipids zegazi, ukunciphisa ubunzima, kwaye iphucule isifo esinxilisayo (Nafld), njl.

I-4. Izigulana zeHypoglycmic: Kwizigulana ezinesifo seswekile 2 yeswekile, i-HBA1C (i-HBA1C (i-Hobling Hemoglobin) incitshisiwe (iimvavanyo zeklinikhi zibonisa ukwehla kwe-1.5%).

5. Iziphumo zokulahleka kwesisindo: Ukulahleka kwesisindo kwizigulana ezityebileyo kunokufikelela kwi-10% ukuya kwi-15% ({3}- iqela ledosi).

6. UKHUSELEKO: Ukuphendula okungaqhelekanga: Ukuphendula okukhulu kubandakanya ukudakumba okuphakathi kwe-gastrointentinal (njengokukhathazeka kunye norhudo), ezifanayo nezo zamachiza ezifanayo.

Iifayile ezishisayo: -}}}}}} ilahleko ye-peptide mazdutide, hina ➢ {{1} {{1} {{1} - -